Installing Lutris itself is as simple as running the following as root:
# xbps-install -S lutris
Setting up Wine support
Lutris can, and will in many cases, download Wine itself. However, in order for it to work properly, you generally want to also install Wine onto your system to ensure that you have all the required dependencies. See the article for Wine for instructions on how to install it.
Setting up support for 32-bit Vulkan games
In addition to that many games simply use Vulkan, Lutris provides the option to use translation layers like DXVK and D9VK to translate DirectX calls to Vulkan for many games. However, many games are still 32-bit, and in the case that you are on a 64-bit Void Linux installation, you will need to install an additional package to enable 32-bit Vulkan support. Note that the multilib repository must be enabled before you can install this package on a 64-bit system.
# xbps-install -S vulkan-loader-32bit